Prompt detection of endogenous hypochlorite (ClO−) in murine macrophages and zebrafish embryos facilitated by a distinctive chemodosimetric mode

Saha, Shrabani; Das, Sujoy; Das, Sriparna; Samanta, Anwesha; Maitra, Sudipta; Sahoo, Prithidipa

dc.contributor.author	Saha, Shrabani
dc.contributor.author	Das, Sujoy
dc.contributor.author	Das, Sriparna
dc.contributor.author	Samanta, Anwesha
dc.contributor.author	Maitra, Sudipta
dc.contributor.author	Sahoo, Prithidipa
dc.date.accessioned	2021-06-01T07:06:53Z
dc.date.available	2021-06-01T07:06:53Z
dc.date.issued	2020-08
dc.identifier.issn	1477-0520 (print) 1477-0539 (web)
dc.identifier.uri	https://vbudspace.lsdiscovery.in/xmlui/handle/123456789/182
dc.description	DOI: 10.1039/d0ob01389g rsc.li/obc	en_US
dc.description.abstract	An innovative fluorescein appended naphthalene diimide based probe (FANDI) has been prepared and characterized to selectively recognize hypochlorite or ClO− ions in the presence of other reactive oxygen species (ROS) and biorelevant ions, using a unique chemodosimetric method. Hypochlorite induced oxi dation can efficiently alter the initial photophysical properties of FANDI and shows an easily detectable “turn on” green fluorescence. The chemodosimeter FANDI can efficiently detect exogenous as well as endogenous ClO− ions in RAW 264.7 cells (macrophages) and zebrafish embryos (Danio rerio) which further ensures the high potential, easy cell permeability and photostability of FANDI and makes it worth exploring in the future	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.relation.ispartofseries	Page No.;6716-6723
dc.subject	Endogenous hypochlorite (ClO−), Murine macrophages, Zebrafish embryos, Chemodosimetric mode	en_US
dc.title	Prompt detection of endogenous hypochlorite (ClO−) in murine macrophages and zebrafish embryos facilitated by a distinctive chemodosimetric mode	en_US
dc.title.alternative	Organic & Biomolecular Chemistry	en_US
dc.type	Article	en_US