Abstract:
Antimicrobial resistance among bacterial strains is an emerging problem, worldwide. Urinary tract infection (UTIs) are one of the
most common bacterial infection in human, both in the community and the hospital settings. Klebsiella pneumonia and Escherichia coli are the
two pre-dominant pathogens commonly isolated in urine. Klebsiella pneumonia is becoming resistant to most of the antibiotic. These
uropathogens have also developed resistance to commonly prescribe antimicrobial agents. The future of antibiogram would be the
incorporation of patient related data to make information more reliable and for predicting outbreaks.
It has been extensively reported that adult women (nearly 75%) have a higher prevalence of UTI than men, primarily owing to anatomic and
physical factors. On the basis of reports by Antimicrobial Surveillance Program, isolate from Canada, USA and Latin American countries
show the lowest susceptibility rates to most antimicrobial agents followed by Asian- Pacific isolates and European strains. The isolated
uropathogens exhibited higher resistance to commonly used oral antibiotic such as ciprofloxacin, amoxicillin/clavulanic acid and Cefepime,
OF 26 Tested antibiotic in this study, the most active antibiotic against Klebsiella pneumonia isolates were Tigecyclin, Fosfomycin and
Colistin.
The result of this study will help in the empiric therapy of infection caused by Klebsiella species in Kolkata, West Bengal but continuous
surverillance of antimicrobial resistance of the organism. This will help authorities to formulate antibiotic prescription policies.
