Screening of different Plant Sources on the Modulation of Murine Antibody Response

Abstract

Different indigenous plants sources, namely, Achyranthes aspera, Bryophyllum, Croton banplandianum, Cissus quadrangularis, Piper longum, Phyllanthus asperlutus, Vanda roxburgi, Cuscuta, Argiman mexicana, Mimordi cakarantia, were screened for the immunomodulating activity in murine system. Ovalbumin along with the aqueous extract of each plant source was injected intraperitoneally into different groups mouse, and to the control group only ovalbumin was given. Antigen-specific antibody response was determined by enzyme linked immunosorbent assay (ELISA). Among these plant sources, aqueous extracts of Achyranthes aspera Piper longum and Coscuta has significantly enhanced the induction of OVA-specific antibody response, but aqueous extract of Mimordi cakarantia has significantly suppressed the induction of OVA specific antibody responses in murine system.